Description

2-Boc-7-Oxo-8-Oxa-2,6-Diaza-Spiro[4.5]Decane is a high-value, protected spirocyclic heterocyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, serving as a key intermediate in the development of novel pharmaceutical candidates. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for novel bifunctional degrader molecules.
• Peptidomimetic Synthesis: Employed to create conformationally constrained peptide analogs with enhanced metabolic stability and receptor selectivity.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	2-Boc-7-Oxo-8-Oxa-2,6-Diaza-Spiro[4.5]Decane
CAS No.	1363382-08-4
Molecular Formula	C12H19N3O4
Molecular Weight	269.30 g/mol
Synonyms	tert-Butyl 7-oxo-8-oxa-2,6-diazaspiro[4.5]decane-2-carboxylate; 2-(tert-Butoxycarbonyl)-7-oxo-8-oxa-2,6-diazaspiro[4.5]decane; 2-Boc-8-oxa-2,6-diazaspiro[4.5]decan-7-one; 2-Boc-7-oxo-8-oxa-2,6-diazaspiro[4.5]decane; 2,6-Diaza-8-oxaspiro[4.5]decan-7-one, 2-[(1,1-dimethylethoxy)carbonyl]-; 1363382-08-4; Boc-protected spirocyclic lactam.
EINECS	Contact for details

Quality Control

Our 2-Boc-7-Oxo-8-Oxa-2,6-Diaza-Spiro[4.5]Decane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material suitable for research use, non-GMP, or cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.