Description

2-Boc-2-Aza-Spiro[3.3]Heptane-6-Methanol is a high-value, protected heterocyclic building block featuring a spirocyclic scaffold and a primary alcohol functional group. This compound is essential for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce constrained spirocyclic motifs, which can improve potency and selectivity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its rigid spiro structure and functional handles for conjugation.
• Chemical Biology Probes: Employed in the creation of tool compounds for target identification and validation in biological pathways.
• Peptidomimetics: The spiro[3.3]heptane core acts as a conformationally restricted scaffold to mimic peptide secondary structures.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	2-Boc-2-Aza-Spiro[3.3]Heptane-6-Methanol
CAS No.	1363381-93-4
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	6-(Hydroxymethyl)-2-aza-2-(tert-butoxycarbonyl)spiro[3.3]heptane; 2-[(tert-Butoxycarbonyl)amino]-2-azaspiro[3.3]heptane-6-methanol; 2-Boc-2-azaspiro[3.3]heptane-6-methanol; tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-6-methanol, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-Boc-2-aza-spiro[3.3]heptane-6-carbinol
EINECS	Contact for details

Quality Control

Our 2-Boc-2-Aza-Spiro[3.3]Heptane-6-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.