Description

2-Azaspiro[4.5]Decane-8-Carboxylic Acid is a high-purity, multifunctional spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained spirocyclic structure containing both a carboxylic acid and a secondary amine functional group makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical and agrochemical R&D organizations for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tools to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, rigid molecular frameworks.

Basic Information

Product Name	2-Azaspiro[4.5]Decane-8-Carboxylic Acid
CAS No.	1363381-86-5
Molecular Formula	C10H17NO2
Molecular Weight	183.25 g/mol
Synonyms	8-Carboxy-2-azaspiro[4.5]decane; 2-Azaspiro[4.5]decan-8-carboxylic acid; 2-Aza-spiro[4.5]decane-8-carboxylic acid; 8-Carboxy-2-azaspiro[4,5]decane; Azaspirodecane carboxylic acid; Spirocyclic proline derivative; 1-Aza-spiro[4.5]decane-8-carboxylic acid (tautomer)
EINECS	Contact for details

Quality Control

Every batch of 2-Azaspiro[4.5]Decane-8-Carboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.