Description

trans-3-Methoxycyclobutanamine Hydrochloride is a high-purity, chiral amine building block essential for advanced pharmaceutical research and development. Its unique cyclobutane scaffold with a methoxy substituent makes it a valuable intermediate for constructing novel, conformationally constrained active pharmaceutical ingredients (APIs). This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel small molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities, particularly for CNS targets.
• Process Chemistry Development: Serves as a starting material or intermediate in the development of scalable synthetic routes for APIs.
• Ligand and Catalyst Synthesis: Potential precursor for creating chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	trans-3-Methoxycyclobutanamine Hydrochloride
CAS No.	1363381-00-3
Molecular Formula	C6H14ClNO
Molecular Weight	151.64 g/mol
Synonyms	trans-3-Methoxycyclobutan-1-amine hydrochloride; (1r,3r)-3-Methoxycyclobutan-1-amine hydrochloride; (1s,3s)-3-Methoxycyclobutan-1-amine hydrochloride; 3-Methoxycyclobutanamine hydrochloride (trans-); Cyclobutanamine, 3-methoxy-, hydrochloride, (1r,3r)-rel-; 1363381-00-3; trans-3-Methoxycyclobutylamine HCl
EINECS	Contact for details

Quality Control

Our trans-3-Methoxycyclobutanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.