Description

Methyl 3-Boc-3-Azabicyclo[3.1.1]Heptane-6-Carboxylate is a high-value, protected bicyclic amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary importance lies in providing a rigid, three-dimensional scaffold that is essential for constructing complex molecular architectures with precise stereochemistry. This compound is particularly vital for pharmaceutical research and development chemists working on novel active pharmaceutical ingredients (APIs), especially in the areas of central nervous system (CNS) drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for neurological and antiviral applications.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to introduce constrained, bicyclic amino acid motifs that mimic peptide secondary structures, enhancing metabolic stability and binding affinity.
• Medicinal Chemistry Scaffold: Provides a versatile, three-dimensional core for constructing focused libraries in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and enzymes.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective reactions to create complex, enantiomerically pure molecules.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and probes for studying biological pathways and protein function.
• Agrochemical Research: Serves as a building block for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	Methyl 3-Boc-3-Azabicyclo[3.1.1]Heptane-6-Carboxylate
CAS No.	1363380-75-9
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	6-(Methoxycarbonyl)-3-azabicyclo[3.1.1]heptane-3-carboxylic acid tert-butyl ester; Methyl 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.1]heptane-6-carboxylate; 3-Boc-3-azabicyclo[3.1.1]heptane-6-carboxylic acid methyl ester; tert-Butyl 6-(methoxycarbonyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate; Bicyclic Boc-protected amino ester; 3-Azabicyclo[3.1.1]heptane-6-carboxylic acid, 3-(1,1-dimethylethyl) ester, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Boc-3-Azabicyclo[3.1.1]Heptane-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.