Description

cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole dihydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters for its role as a key chiral scaffold in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecular architectures where precise stereochemistry and high purity are critical for biological activity and process scalability.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• API Development: Used in research and process development for Active Pharmaceutical Ingredients (APIs) requiring a fused bicyclic pyrrolidine core structure.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and potential for derivatization.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in catalytic asymmetric reactions to introduce stereocenters.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and nitrogen-containing compound synthesis.

Basic Information

Product Name	cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole dihydrochloride
CAS No.	1363166-00-0
Molecular Formula	C8H16N2·2HCl
Molecular Weight	213.14 g/mol
Synonyms	5-Methylhexahydropyrrolo[3,4-b]pyrrole dihydrochloride; (3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrole dihydrochloride; cis-5-Methyloctahydropyrrolo[3,4-b]pyrrole dihydrochloride; 1H-Pyrrolo[3,4-b]pyrrole, hexahydro-5-methyl-, dihydrochloride, cis-; Bicyclic pyrrolidine dihydrochloride; 5-Methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrole dihydrochloride
EINECS	Contact for details

Quality Control

Our cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Production adheres to cGMP guidelines where applicable, and all materials are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.