Description

Spiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing spirocyclic scaffolds, which are prized for their three-dimensionality and potential to improve drug-like properties.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial R&D labs for exploring new chemical entities and reaction pathways.
• Agrochemical Synthesis: Used in the development of new generation pesticides and herbicides that require sophisticated heterocyclic structures.
• Material Science Research: Investigated for potential applications in creating novel organic electronic materials or ligands for catalysis.

Basic Information

Item	Details
Product Name	Spiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One
CAS No.	1363165-92-7
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	Spiro[cyclobutane-1,2'-[1,2,3,4]tetrahydroquinazolin]-4'-one; 1',2',3',4'-Tetrahydrospiro[cyclobutane-1,2-quinazolin]-4-one; 1363165-92-7; Spirotetrahydroquinazoline cyclobutaneone; Tetrahydrospiro[cyclobutane-1,2-quinazolin]-4(1H)-one
EINECS	Contact for details

Quality Control

Our Spiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, including cGMP-grade material for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.