Description

Methyl 3-(4-((tert-Butoxycarbonylamino)Methyl)Phenylsulfonyl)Propanoate is a high-purity, advanced pharmaceutical intermediate featuring a sulfonyl linker and a Boc-protected amine group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile handle for further functionalization and peptide coupling strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Protease Inhibitor Development: Used in the research and production of potential inhibitors for various proteolytic enzymes.
• Peptidomimetic Synthesis: Serves as a crucial component for constructing peptide-like molecules with enhanced stability and bioavailability.
• Bioconjugation & Linker Chemistry: The reactive sulfonyl propanoate ester and protected amine facilitate its use as a linker in antibody-drug conjugates (ADCs) and other bioconjugation platforms.
• Chemical Biology Research: Employed as a tool compound or probe in studying enzyme-substrate interactions and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	Methyl 3-(4-((tert-Butoxycarbonylamino)Methyl)Phenylsulfonyl)Propanoate
CAS No.	1362160-41-5
Molecular Formula	C16H23NO6S
Molecular Weight	357.42 g/mol
Synonyms	Methyl 3-[4-[[(tert-Butoxycarbonyl)amino]methyl]phenylsulfonyl]propanoate; Boc-NH-CH2-Ph-SO2-(CH2)2-COOCH3; 3-[4-[[(tert-Butoxycarbonylamino)methyl]phenyl]sulfonyl]propanoic Acid Methyl Ester; 4-((Boc-amino)methyl)benzenesulfonylpropionic Acid Methyl Ester; (4-((tert-Butoxycarbonylamino)methyl)phenyl)sulfonyl Propanoic Acid Methyl Ester; Methyl 3-(4-(Boc-aminomethyl)phenylsulfonyl)propionate; Boc-Amino-PEG2-SO2-Ph-OMe; Pharmaceutical Intermediate 1362160-41-5
EINECS	Contact for details

Quality Control

Our Methyl 3-(4-((tert-Butoxycarbonylamino)Methyl)Phenylsulfonyl)Propanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, from research to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive (hygroscopic) and should be handled under anhydrous conditions when possible. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.