Description

5'-(Trifluoromethyl)-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound matters for its critical role in modern medicinal chemistry, where its structure serves as a versatile building block for developing novel bioactive molecules. Pharmaceutical R&D and fine chemical synthesis professionals need it to create potential drug candidates targeting a range of therapeutic areas, including central nervous system disorders and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic and trifluoromethyl motifs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Agrochemical Research: Employed in the discovery of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating biological pathways and target validation.
• Academic & Contract Research: Essential for exploratory synthetic chemistry and methodology development in academic and CRO settings.

Basic Information

Product Name	5'-(Trifluoromethyl)-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1360898-86-7
Molecular Formula	C11H8F3NO
Molecular Weight	227.18 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-(trifluoromethyl)-; 5-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one; Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-(trifluoromethyl)-; 1360898-86-7; 5'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one; 5-(Trifluoromethyl)-1'H-spiro[cyclopropane-1,3'-indole]-2'-one
EINECS	Contact for details

Quality Control

Our 5'-(Trifluoromethyl)-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to cGMP principles and ISO standards ensures a reliable supply of this high-purity intermediate for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.