Description

1,4-Dibromo-2,3-difluoro-5-nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it a versatile precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates where the difluoro motif can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging the reactivity of the bromine atoms and the electron-withdrawing nitro group.
• Material Science Precursor: Serves as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and polymers, where halogenated aromatics are critical for tuning material properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), allowing for the introduction of complex aryl groups into molecular frameworks.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups facilitate nucleophilic substitution reactions, enabling the introduction of amines, alkoxides, and other nucleophiles.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry research to explore new synthetic routes and create compound libraries for screening.

Basic Information

Product Name	1,4-Dibromo-2,3-difluoro-5-nitrobenzene
CAS No.	1360726-52-8
Molecular Formula	C6HBr2F2NO2
Molecular Weight	315.88 g/mol
Synonyms	2,3-Difluoro-1,4-dibromo-5-nitrobenzene; 1,4-Dibromo-2,3-difluoronitrobenzene; Benzene, 1,4-dibromo-2,3-difluoro-5-nitro-; 5-Nitro-1,4-dibromo-2,3-difluorobenzene; 2,3-Difluoro-5-nitro-1,4-dibromobenzene
EINECS	Contact for details

Quality Control

Our 1,4-Dibromo-2,3-difluoro-5-nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports your R&D and scale-up processes with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.