Description

4-(tert-Butyldimethylsilyloxy)-N1-Methylbenzene-1,2-Diamine is a high-purity, advanced pharmaceutical intermediate featuring a protected diamine and phenol functionality. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly in the development of targeted small-molecule therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring protected amine and phenol groups for selective reactions.
• Organic Synthesis Reagent: Used in research and development for constructing heterocyclic compounds and other sophisticated molecular architectures.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group serves as a robust protecting group for the phenol, allowing for orthogonal deprotection strategies in multi-step syntheses.
• Agrochemical Research: Potential intermediate in the development of new herbicides, fungicides, or plant growth regulators requiring specific diamine backbones.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers, ligands for catalysis, or organic electronic materials.

Basic Information

Product Name	4-(tert-Butyldimethylsilyloxy)-N1-Methylbenzene-1,2-Diamine
CAS No.	1359704-14-5
Molecular Formula	C13H24N2OSi
Molecular Weight	252.43 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]-N1-methylbenzene-1,2-diamine; 1,2-Benzenediamine, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-N1-methyl-; N1-Methyl-4-(tert-butyldimethylsilyloxy)-1,2-phenylenediamine; 4-(TBDMS-Oxy)-N1-methyl-o-phenylenediamine; 4-(tert-Butyldimethylsiloxy)-N-methyl-1,2-diaminobenzene; TBDMS-protected N-methyl-diaminophenol
EINECS	Contact for details

Quality Control

Our production of 4-(tert-Butyldimethylsilyloxy)-N1-Methylbenzene-1,2-Diamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.