Description

trans-Hexahydro-Pyrrolo[3,2-B]Pyrrole-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a rigid, bicyclic pyrrolidine scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with enhanced three-dimensional character. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly for central nervous system (CNS) and metabolic disease targets. The CAS number for this compound is 1357353-61-7.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development programs.
• Protease Inhibitor Scaffold: Serves as a core structural element in the design and synthesis of novel protease inhibitors, including DPP-4 and DPP-8 inhibitors for diabetes treatment.
• Chemical Biology Tool: Used in the preparation of specialized probes and ligands for studying enzyme function and receptor binding.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective synthesis to introduce defined stereocenters.
• Peptidomimetic Research: Integral to creating peptidomimetics where the bicyclic structure mimics peptide turn conformations, enhancing metabolic stability.
• Library Synthesis for HTS: Used in parallel and combinatorial chemistry to generate focused libraries for high-throughput screening (HTS) against various biological targets.

Basic Information

Product Name	trans-Hexahydro-Pyrrolo[3,2-B]Pyrrole-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester
CAS No.	1357353-61-7
Molecular Formula	C20H28N2O4
Molecular Weight	360.45 g/mol
Synonyms	(3aR,6aR)-1-(Benzyloxycarbonyl)hexahydropyrrolo[3,2-b]pyrrole-4(1H)-carboxylic acid tert-butyl ester; (3aR,6aR)-1-[(Benzyloxy)carbonyl]octahydro-2H-pyrrolo[3,2-b]pyrrole-4-carboxylic acid tert-butyl ester; 1-Benzyl 4-tert-butyl (3aR,6aR)-hexahydro-2H-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylate; trans-1-N-Cbz-4-N-Boc-Octahydropyrrolo[3,2-b]pyrrole; (3aR,6aR)-1-Cbz-4-Boc-Octahydropyrrolo[3,2-b]pyrrole; Bicyclic Pyrrolidine Ester Intermediate; Cbz-Boc-Protected Bicyclic Diamine
EINECS	Contact for details

Quality Control

Our trans-Hexahydro-Pyrrolo[3,2-B]Pyrrole-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.