Description

3-(3-Fluoro-2-Nitrophenoxy)Oxetane is a high-purity, advanced pharmaceutical intermediate characterized by its unique oxetane and fluoronitro aromatic structure. This compound is critical for medicinal chemistry research, particularly in the development of novel small-molecule therapeutics where its scaffold offers valuable properties for drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated, heterocyclic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorinated oxetane groups on potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Acts as a precursor in the development of new-generation herbicides and pesticides with enhanced efficacy and environmental profiles.
• Material Science: Investigated as a monomer or cross-linking agent for creating specialized polymers with tailored thermal and chemical resistance.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-(3-Fluoro-2-Nitrophenoxy)Oxetane
CAS No.	1356114-13-0
Molecular Formula	C9H8FNO4
Molecular Weight	213.16 g/mol
Synonyms	Oxetane, 3-[(3-fluoro-2-nitrophenyl)oxy]-; 3-(3-Fluoro-2-nitrophenoxy)oxetane; 3-[(3-Fluoro-2-nitrophenyl)oxy]oxetane; 3-(3-Fluoro-2-nitro-phenoxy)-oxetane; 1356114-13-0; 3-(3-Fluoro-2-nitrophenoxy)oxacyclobutane
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Fluoro-2-Nitrophenoxy)Oxetane is produced under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A Certificate of Analysis (COA) is provided with each shipment, documenting results from tests including HPLC, NMR, and mass spectrometry. We support development and commercial projects with scalable, cGMP-compliant manufacturing options upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under inert atmosphere for long-term stability. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.