Description

(S)-1-Cyclobutylethanamine Hydrochloride is a high-purity chiral amine salt, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined cyclobutyl scaffold, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and advanced agrochemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical transformations to produce enantiomerically pure compounds.
• Peptidomimetics & Bioisosteres: Incorporates the constrained cyclobutane ring into peptide backbones to improve pharmacokinetic properties and receptor binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for novel ligands in transition metal catalysis and organocatalysis.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents with specific modes of action.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(S)-1-Cyclobutylethanamine Hydrochloride
CAS No.	1355969-30-0
Molecular Formula	C6H14ClN
Molecular Weight	135.64 g/mol
Synonyms	(S)-1-Cyclobutylethylamine hydrochloride; (1S)-1-Cyclobutylethan-1-amine hydrochloride; (S)-(-)-1-Cyclobutylethylamine HCl; (S)-α-Methylcyclobutanemethylamine hydrochloride; (S)-1-Amino-1-cyclobutylethane hydrochloride; (S)-1-Cyclobutyl-1-aminoethane HCl; (S)-Cyclobutylmethylamine, α-methyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Cyclobutylethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.