Description

21-Chloro-3,6,9,12,15-Pentaoxahenicosan-1-Ol is a specialized polyether compound featuring a terminal chloro group and a terminal hydroxyl group, separated by a polyethylene glycol (PEG) spacer. This unique bifunctional structure makes it a valuable PEG linker and building block for chemical synthesis, enabling the modification of molecules to enhance solubility, stability, and biocompatibility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for creating novel drug conjugates, diagnostic agents, and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key linker in the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutic agents.
• Bioconjugation Reagent: Used to PEGylate peptides, proteins, and oligonucleotides to improve their pharmacokinetic profiles and reduce immunogenicity.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent for creating hydrogels, smart materials, and non-ionic surfactants with tailored properties.
• Surface Modification: Employed to functionalize nanoparticles, quantum dots, and other nanomaterials to enhance dispersion and biocompatibility for diagnostic and imaging applications.
• Chemical Probe Synthesis: A versatile building block for constructing fluorescent dyes, sensor molecules, and other research tools with hydrophilic spacers.
• Cosmetic & Personal Care: Potential use in formulating advanced delivery systems for active ingredients in skincare products.

Basic Information

Item	Detail
Product Name	21-Chloro-3,6,9,12,15-Pentaoxahenicosan-1-Ol
CAS No.	1355956-01-2
Molecular Formula	C16H33ClO6
Molecular Weight	356.88 g/mol
Synonyms	21-Chloro-3,6,9,12,15-pentaoxahenicosan-1-ol; 2-[2-[2-[2-[2-(2-Chloroethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 17-Chloro-3,6,9,12,15-pentaoxaheptadecan-1-ol (common numbering variation); PEG5 Chlorohydrin; α-Chloro-ω-hydroxy-pentaethylene glycol; Hexaethylene glycol monochlorohydrin; HO-PEG5-Cl; Chloro-PEG5-alcohol
EINECS	Contact for details

Quality Control

Our 21-Chloro-3,6,9,12,15-Pentaoxahenicosan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.