Description

n-(3,3-Difluorocyclobutyl)Formamide is a specialized organic building block featuring a difluorocyclobutyl moiety. This compound is valued for its unique structural properties, serving as a critical intermediate in modern synthetic chemistry, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with targeted functionalities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, especially those requiring fluorinated cyclobutane scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the difluorocyclobutyl group can influence biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the synthesis of fluorinated polymers or specialty chemicals with unique surface properties or thermal stability.
• Chemical Biology Probes: Useful for constructing molecular probes to study enzyme mechanisms or protein-ligand interactions in biological systems.

Basic Information

Product Name	n-(3,3-Difluorocyclobutyl)Formamide
CAS No.	1355328-30-1
Molecular Formula	C5H7F2NO
Molecular Weight	135.11 g/mol
Synonyms	N-(3,3-Difluorocyclobutyl)formamide; 3,3-Difluorocyclobutane-1-carboxamide; Formamide, N-(3,3-difluorocyclobutyl)-; 1-Amino-3,3-difluorocyclobutane-1-carboxaldehyde (tautomeric form); Difluorocyclobutylformamide
EINECS	Contact for details

Quality Control

Our n-(3,3-Difluorocyclobutyl)Formamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.