Description

Propargyl-Peg6-T-Butyl Ester is a functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a tert-butyl ester, designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and manufacturers requiring precise, stable, and efficient coupling reactions to modify biomolecules, polymers, and surfaces. It is primarily needed by the pharmaceutical, biotechnology, and advanced materials sectors for drug delivery system development, diagnostic probe synthesis, and the creation of functional hydrogels.

Application

• Bioconjugation Linker: Serves as a key intermediate in the synthesis of antibody-drug conjugates (ADCs), peptide-drug conjugates, and protein-polymer hybrids via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Polymer Functionalization: Used to introduce reactive alkyne handles onto polymer backbones or nanoparticles for subsequent modification with azide-containing ligands, dyes, or drugs.
• Surface Engineering: Enables the functionalization of biosensor chips, microarray slides, and other solid supports with PEG spacers to create non-fouling, bioactive surfaces.
• Cross-linking Agent: Acts as a cross-linker in the formation of hydrogels and biomaterials with tailored degradation profiles and mechanical properties for tissue engineering.
• Diagnostic Reagent Synthesis: Employed in the preparation of fluorescent probes, MRI contrast agents, and other diagnostic tools by conjugating reporting molecules to targeting vectors.
• Prodrug Development: Facilitates the attachment of therapeutic agents to solubilizing PEG chains or cleavable linkers to create prodrugs with improved pharmacokinetics.

Basic Information

Product Name	Propargyl-Peg6-T-Butyl Ester
CAS No.	1355197-95-3
Molecular Formula	C25H46O9
Molecular Weight	490.63 g/mol
Synonyms	Propargyl-PEG6-t-butyl ester; 2,5,8,11,14,17-Hexaoxanonadec-18-ynoic acid 1,1-dimethylethyl ester; t-Butyl-PEG6-propargyl; Propargyl-PEG6-OtBu; tert-Butyl 2,5,8,11,14,17-hexaoxanonadec-18-ynoate; Propargyl hexaethylene glycol mono-tert-butyl ether ester; Alkyne-PEG6-t-butyl ester; Propargyl-PEG6-acid t-butyl ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg6-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.