Description

(3R)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative of significant importance in modern pharmaceutical research and development. This chiral building block is specifically designed for the synthesis of complex, biologically active molecules, offering a critical handle for structure-activity relationship (SAR) studies. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates, particularly in areas requiring fluorinated pharmacophores.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for CNS and anti-infective drugs.
• Peptidomimetics & PROTACs: Serves as a crucial component in the design and synthesis of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Fluorinated Compound Libraries: Used in combinatorial chemistry and high-throughput screening to build diverse libraries of fluorinated compounds for drug discovery.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to introduce chirality into target molecules.
• Agrochemical Research: Potential application in the development of advanced, fluorinated agrochemicals and pesticides.
• Bioconjugation & Linker Chemistry: The amino and carboxylic acid functional groups make it suitable for use as a linker in antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	(3R)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride
CAS No.	1354970-81-2
Molecular Formula	C9H9F2NO2 • HCl
Molecular Weight	239.63 (Free base) / 276.09 (HCl salt)
Synonyms	(R)-3-Amino-3-(2,4-difluorophenyl)propanoic acid hydrochloride; (3R)-3-Amino-3-(2,4-difluorophenyl)propionic acid HCl; D-3-Amino-3-(2,4-difluorophenyl)propanoic acid hydrochloride; (R)-3-Amino-3-(2,4-difluorophenyl)propanoate hydrochloride; 2,4-Difluoro-D-β-homophenylalanine hydrochloride; (R)-2,4-Difluoro-β-homophenylalanine hydrochloride; (R)-3-Amino-3-(2,4-difluorophenyl)propanoic acid monohydrochloride
EINECS	Contact for details

Quality Control

Our (3R)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (>99%), and impurity profiles is provided with every shipment to guarantee reproducible results for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.