Description

1,1,1-Trifluoro-2-Methylbutan-2-Amine Hydrochloride is a high-purity fluorinated amine hydrochloride salt, a key building block in advanced organic synthesis. This compound is valued for its unique trifluoromethyl group, which imparts desirable metabolic stability and lipophilicity to target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine moiety enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with specific surface properties and chemical resistance.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein interactions.

Basic Information

Product Name	1,1,1-Trifluoro-2-Methylbutan-2-Amine Hydrochloride
CAS No.	1354952-99-0
Molecular Formula	C5H11ClF3N
Molecular Weight	177.60 g/mol
Synonyms	2-Amino-2-methyl-4,4,4-trifluorobutane Hydrochloride; 2-Methyl-1,1,1-trifluorobutan-2-amine Hydrochloride; 4,4,4-Trifluoro-2-methylbutan-2-amine Hydrochloride; 1,1,1-Trifluoro-2-amino-2-methylbutane HCl; α-Methyl-α-(trifluoromethyl)propylamine Hydrochloride; 2-Methyl-4,4,4-trifluorobutan-2-amine Hydrochloride; 2-(Trifluoromethyl)-2-butanamine Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development use. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a strict quality management system to guarantee batch-to-batch consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture uptake. Recommended long-term storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.