Description

(4-Methyl-Benzyl)-(R)-Pyrrolidin-3-Yl-Amine Hydrochloride is a high-purity chiral amine building block and salt form, essential for advanced pharmaceutical research and development. Its value lies in its role as a key intermediate for synthesizing active pharmaceutical ingredients (APIs) and other biologically active molecules, particularly in the field of asymmetric synthesis. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key structural component in the development of new APIs, where the (R)-enantiomer configuration is required for specific biological activity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and protein function.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for commercial pharmaceutical manufacturing.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in cutting-edge organic and medicinal chemistry projects.

Basic Information

Product Name	(4-Methyl-Benzyl)-(R)-Pyrrolidin-3-Yl-Amine Hydrochloride
CAS No.	1354020-90-8
Molecular Formula	C13H21ClN2
Molecular Weight	240.77 g/mol
Synonyms	(R)-1-(4-Methylbenzyl)-3-aminopyrrolidine hydrochloride; (R)-3-Amino-1-(4-methylbenzyl)pyrrolidine hydrochloride; (R)-1-(p-Tolylmethyl)-3-pyrrolidinamine hydrochloride; (R)-N-[(4-Methylphenyl)methyl]-3-pyrrolidinamine hydrochloride; (R)-1-(4-Methylbenzyl)pyrrolidin-3-amine hydrochloride; (R)-1-(p-Methylbenzyl)-3-aminopyrrolidine HCl; (R)-3-Amino-1-(p-tolylmethyl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (4-Methyl-Benzyl)-(R)-Pyrrolidin-3-Yl-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, residual solvents, and other critical parameters is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.