Description

(R)-3-Iodo-Pyrrolidine Hydrochloride is a high-purity chiral building block and key intermediate in advanced organic synthesis. This compound is particularly valued for its role in constructing complex molecular architectures, especially in the development of active pharmaceutical ingredients (APIs) and bioactive molecules. It is an essential material for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce stereochemistry and functional diversity into their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space and improve drug candidate properties.
• Asymmetric Synthesis: Serves as a versatile precursor for the construction of complex, enantiomerically pure nitrogen-containing heterocycles via cross-coupling and substitution reactions.
• Agrochemical Research: Employed in the synthesis of chiral active ingredients for crop protection products.
• Ligand and Catalyst Development: Useful for creating novel chiral ligands and organocatalysts for asymmetric transformations.
• Chemical Biology Probes: Acts as a building block for synthesizing molecular probes to study biological pathways and protein function.

Basic Information

Product Name	(R)-3-Iodo-Pyrrolidine Hydrochloride
CAS No.	1353997-17-7
Molecular Formula	C4H9IN•HCl
Molecular Weight	233.49 g/mol
Synonyms	(R)-3-Iodopyrrolidine hydrochloride; (R)-3-Iodopyrrolidine HCl; (3R)-3-Iodopyrrolidine hydrochloride; (R)-3-Iodo-1-azacyclopentane hydrochloride; Pyrrolidine, 3-iodo-, hydrochloride, (3R)-; (R)-N-Iodopyrrolidine hydrochloride; (R)-3-Iodopyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our (R)-3-Iodo-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.