Description

(S)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride is a high-purity chiral building block and intermediate of significant value in advanced organic synthesis. This compound is crucial for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and functional groups.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and commercial synthesis of target APIs.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Potential precursor for the synthesis of novel chiral ligands or organocatalysts.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride
CAS No.	1353995-35-3
Molecular Formula	C10H12ClFNS
Molecular Weight	231.72 g/mol
Synonyms	(S)-3-[(4-Fluorophenyl)thio]pyrrolidine hydrochloride; (3S)-3-[(4-Fluorophenyl)sulfanyl]pyrrolidine hydrochloride; Pyrrolidine, 3-[(4-fluorophenyl)thio]-, hydrochloride, (3S)-; (S)-3-(4-Fluorophenylthio)pyrrolidine HCl; (S)-3-(p-Fluorophenylthio)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.