Description

2-{[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Methyl}-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs. It is primarily sought after by pharmaceutical R&D teams, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in drug discovery.
• API Synthesis: Used in the production route of final Active Pharmaceutical Ingredients, where its specific stereochemistry and functional groups are essential.
• Protease Inhibitor Development: The pyrrolidine-carboxylate moiety suggests potential application in the synthesis of protease inhibitor libraries for antiviral or anticancer research.
• Custom Synthesis & Scale-Up: A key material for contract manufacturing organizations (CMOs) offering custom synthesis services from gram to kilogram scale for clinical trial material production.

Basic Information

Product Name	2-{[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Methyl}-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353974-16-9
Molecular Formula	C17H22ClN3O3
Molecular Weight	351.83 g/mol
Synonyms	tert-Butyl 2-({[(2-chloropyridin-3-yl)carbonyl]amino}methyl)pyrrolidine-1-carboxylate; 1-Boc-2-({[(2-chloropyridin-3-yl)carbonyl]amino}methyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-({[(2-chloropyridin-3-yl)carbonyl]amino}methyl)pyrrolidine; 2-({[(2-Chloropyridine-3-carbonyl)amino]methyl})pyrrolidine-1-carboxylic acid tert-butyl ester; (2-Chloro-pyridine-3-carbonyl)-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; 1353974-16-9; UNII-9J1GX23U4P
EINECS	Contact for details

Quality Control

Our 2-{[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Methyl}-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.