Description

Dnp-Peg2-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a 2,4-dinitrophenyl (Dnp) protecting group and a terminal carboxylic acid. This compound is a crucial intermediate in bioconjugation and pharmaceutical development, enabling the controlled synthesis of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and advanced drug delivery systems.

Application

• Bioconjugation Reagent: Used as a versatile linker for attaching peptides, proteins, or other biomolecules to surfaces, nanoparticles, or drug payloads.
• Protecting Group Chemistry: The Dnp group serves as a photolabile or chemically cleavable protecting group for amines in multi-step organic synthesis.
• PEGylation Intermediate: A key building block for creating PEGylated therapeutics to improve solubility, stability, and pharmacokinetic profiles.
• Crosslinking Agent: Facilitates the formation of stable amide bonds between molecules, useful in material science and hydrogel formation.
• Proteomics Research: Employed in the study of protein-protein interactions and the development of activity-based probes.
• Antibody-Drug Conjugate (ADC) Development: Serves as a component in the linker-payload construct for targeted cancer therapies.

Basic Information

Product Name	Dnp-Peg2-Acid
CAS No.	1353011-89-8
Molecular Formula	C₁₇H₂₄N₂O₉
Molecular Weight	400.38 g/mol
Synonyms	2,4-Dinitrophenyl-PEG2-acid; 2-[2-[2-(2,4-Dinitroanilino)ethoxy]ethoxy]acetic Acid; DNP-PEG2-COOH; 2,4-DNP-PEG2-acid; 2-(2-(2-(2,4-Dinitrophenylamino)ethoxy)ethoxy)acetic Acid; DNP-PEG2-CH2COOH; (2,4-Dinitrophenylamino)-diethylene glycol acetic acid
EINECS	Contact for details

Quality Control

Our Dnp-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.