Description

Methyl 2-Amino-4-Chloro-8-Methoxyquinazoline-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1352925-79-1. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, especially within oncology and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic targets.
• Oncology Drug Development: Serves as a core scaffold for developing targeted cancer therapies due to the quinazoline pharmacophore.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and novel synthetic pathways.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into multi-step synthetic routes for producing complex final active ingredients.

Basic Information

Product Name	Methyl 2-Amino-4-Chloro-8-Methoxyquinazoline-5-Carboxylate
CAS No.	1352925-79-1
Molecular Formula	C11H10ClN3O3
Molecular Weight	267.67 g/mol
Synonyms	Methyl 2-amino-4-chloro-8-methoxyquinazoline-5-carboxylate; 2-Amino-4-chloro-8-methoxyquinazoline-5-carboxylic acid methyl ester; 5-Quinazolinecarboxylic acid, 2-amino-4-chloro-8-methoxy-, methyl ester; 1352925-79-1; Methyl 2-amino-4-chloro-8-methoxy-5-quinazolinecarboxylate; 4-Chloro-8-methoxy-2-aminoquinazoline-5-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-Chloro-8-Methoxyquinazoline-5-Carboxylate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.