Description

1-(T-Boc-Aminooxy)-3-Aminooxy-Propane is a specialized bifunctional linker molecule featuring two aminooxy groups, one of which is protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for the controlled conjugation of carbonyl-containing molecules, such as ketones and aldehydes, in aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for the synthesis of antibody-drug conjugates (ADCs), protein labeling, and the development of advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a heterobifunctional linker for connecting cytotoxic payloads to monoclonal antibodies via oxime bond formation.
• Protein and Peptide Modification: Enables site-specific labeling and functionalization of proteins, peptides, and other biomolecules containing ketone or aldehyde tags.
• Bioconjugation Reagent: Used in the development of diagnostic assays, imaging probes, and biosensors that require stable oxime linkages.
• Chemical Biology Research: A valuable tool for studying protein function, interactions, and localization through bioorthogonal chemistry.
• Material Science: Applied in surface functionalization and the creation of smart materials with specific biorecognition properties.

Basic Information

Product Name	1-(T-Boc-Aminooxy)-3-Aminooxy-Propane
CAS No.	1352546-80-5
Molecular Formula	C12H24N2O5
Molecular Weight	276.33 g/mol
Synonyms	1-(tert-Butoxycarbonylaminooxy)-3-aminooxypropane; 3-(Boc-Aminooxy)-1-aminooxypropane; 1,3-Bis(aminooxy)propane, 1-Boc protected; N-Boc-3-aminooxypropyl-O-amine; Boc-Aminooxy-PEG1-Aminooxy; Boc-AOA-PEG1-AOA; Heterobifunctional Aminooxy Linker; ADC Linker with Boc and Aminooxy groups
EINECS	Contact for details

Quality Control

Our 1-(T-Boc-Aminooxy)-3-Aminooxy-Propane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the high standards of pharmaceutical development and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.