Description

1-Bromo-2-Fluoro-4-Methoxy-3-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated and nitro-substituted aromatic rings.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the bromo and fluoro substituents can modulate biological activity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro group and halogen atoms.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups facilitate nucleophilic substitution reactions, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Dye and Pigment Intermediate: Can be used in the development of specialized nitroaromatic dyes and pigments.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-Methoxy-3-Nitrobenzene
CAS No.	1352317-80-6
Molecular Formula	C7H5BrFNO3
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-1-Fluoro-4-Methoxy-5-Nitrobenzene; 3-Nitro-4-Methoxy-2-Fluorobromobenzene; Benzene, 1-bromo-2-fluoro-4-methoxy-3-nitro-; 4-Methoxy-3-nitro-2-fluorobromobenzene; 2-Fluoro-4-methoxy-3-nitro-1-bromobenzene; 1-Bromo-2-fluoro-4-methoxy-3-nitro-benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4-Methoxy-3-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound should be considered light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.