Description

5-Bromo-2-Fluoro-3-Methylanisole is a high-purity, multi-functional aromatic building block characterized by its bromo, fluoro, and methoxy substituents. This compound is critical for advanced organic synthesis, offering precise reactivity for constructing complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry for introducing halogenated aromatic motifs.
• Agrochemical Synthesis: Serves as a versatile precursor for creating advanced herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated anisole structure.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, leveraging the bromine substituent.
• Fluorine Chemistry Building Block: The presence of both fluorine and bromine makes it valuable for exploring structure-activity relationships (SAR) in fluorinated compound libraries.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Methylanisole
CAS No.	1351668-20-6
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-Bromo-4-fluoro-5-methoxy-2-methylbenzene; 3-Methyl-5-bromo-2-fluoroanisole; 2-Fluoro-5-bromo-3-methylanisole; Benzene, 1-bromo-4-fluoro-5-methoxy-2-methyl-; 5-Bromo-2-fluoro-3-methoxy-1-methylbenzene; 5-Bromo-2-fluoro-3-methyl-1-methoxybenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-3-Methylanisole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.