Description

trans-1,3-Cyclobutanediamine is a high-purity, stereochemically defined diamine building block with significant utility in advanced organic synthesis. Its rigid, bicyclic structure and two primary amine functionalities make it a valuable precursor for constructing complex molecular architectures, particularly in pharmaceutical and materials science research. This compound is essential for chemists and R&D teams developing novel active pharmaceutical ingredients (APIs), chiral ligands, and high-performance polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalyst Ligand: Used to develop proprietary chiral ligands for transition metal catalysis, enabling enantioselective synthesis.
• Polymer & Resin Modifier: Serves as a curing agent or chain extender in epoxy and polyurethane systems, imparting rigidity and thermal stability.
• Chelating Agent Precursor: The basis for synthesizing specialized chelators used in metal scavenging, catalysis, and diagnostic imaging agents.
• High-Performance Material Synthesis: Incorporated into polyamides, polyimides, and other engineering plastics to enhance mechanical properties.
• Agrochemical Intermediate: Used in the research and development of new generation herbicides and fungicides with specific stereochemical requirements.

Basic Information

Product Name	trans-1,3-Cyclobutanediamine
CAS No.	1350753-06-8
Molecular Formula	C4H10N2
Molecular Weight	86.14 g/mol
Synonyms	(1R,3S)-1,3-Cyclobutanediamine; (1S,3R)-1,3-Cyclobutanediamine; trans-Cyclobutane-1,3-diamine; rel-(1R,3S)-1,3-Cyclobutanediamine; 1,3-Cyclobutanediamine, trans-; 1,3-Diaminocyclobutane, trans-; (R*,S*)-1,3-Cyclobutanediamine
EINECS	Contact for details

Quality Control

Our trans-1,3-Cyclobutanediamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements of research and process development. A detailed Certificate of Analysis (COA) providing full specifications, including assay, enantiomeric excess, and impurity profiles, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.