Description

3-[4-(Trifluoromethyl)Phenyl]Oxetan-3-Amine Hydrochloride is a high-value pharmaceutical intermediate and building block characterized by its unique oxetane and trifluoromethylphenyl pharmacophores. This compound matters for its critical role in modern medicinal chemistry, where it serves as a versatile scaffold for constructing novel bioactive molecules, particularly in drug discovery programs targeting CNS disorders and inflammatory conditions. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new therapeutic candidates with improved metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and anti-inflammatory targets.
• Medicinal Chemistry Research: Used as a constrained amine scaffold in structure-activity relationship (SAR) studies and lead optimization to modulate physicochemical properties.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Synthesis: Employed in the research and development of advanced crop protection agents with enhanced efficacy.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced materials.

Basic Information

Product Name	3-[4-(Trifluoromethyl)Phenyl]Oxetan-3-Amine Hydrochloride
CAS No.	1349718-44-0
Molecular Formula	C10H9F3NO•HCl
Molecular Weight	251.64 g/mol (Free base: 215.18 g/mol)
Synonyms	3-Amino-3-[4-(trifluoromethyl)phenyl]oxetane hydrochloride; 3-(4-(Trifluoromethyl)phenyl)oxetan-3-amine HCl; 4-(3-Aminooxetan-3-yl)benzotrifluoride hydrochloride; Oxetan-3-amine, 3-[4-(trifluoromethyl)phenyl]-, hydrochloride; 1349718-44-0; 3-(4-Trifluoromethylphenyl)-3-aminooxetane hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[4-(Trifluoromethyl)Phenyl]Oxetan-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.