Description

tert-Butyl 4-(2-Chloro-6-Fluorobenzylamino)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and receptor-targeting drugs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• API Development: Used in the research and scale-up production of Active Pharmaceutical Ingredients (APIs) with complex molecular architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in route scouting and the development of robust, scalable synthetic pathways for commercial manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary compounds for clinical trials.
• Biochemical Research: Used in the development of biochemical probes and tool compounds for studying biological pathways and protein interactions.

Basic Information

Product Name	tert-Butyl 4-(2-Chloro-6-Fluorobenzylamino)Piperidine-1-Carboxylate
CAS No.	1349717-09-4
Molecular Formula	C17H24ClFN2O2
Molecular Weight	342.84 g/mol
Synonyms	1-Boc-4-[(2-Chloro-6-fluorobenzyl)amino]piperidine; 4-[(2-Chloro-6-fluorophenyl)methyl]amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-{[(2-chloro-6-fluorophenyl)methyl]amino}piperidine-1-carboxylate; 1,1-Dimethylethyl 4-[[(2-chloro-6-fluorophenyl)methyl]amino]-1-piperidinecarboxylate; 4-(2-Chloro-6-fluorobenzylamino)piperidine-1-carboxylic acid tert-butyl ester; N-(2-Chloro-6-fluorobenzyl)-N-(1-Boc-piperidin-4-yl)amine; Boc-4-(2-Chloro-6-fluorobenzylamino)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Chloro-6-Fluorobenzylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.