Description

n-(3-Fluoro-5-Methylbenzyl)Piperidin-4-Amine Dihydrochloride is a high-purity, pharmaceutically relevant intermediate characterized by its piperidine amine core and fluorinated benzyl moiety. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in neurological and psychiatric disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable amine and fluorinated aromatic structure.
• Chemical Biology Probes: Serves as a precursor for developing tool compounds and probes to study biological pathways and protein function.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized, non-commercial compounds for client R&D projects.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	n-(3-Fluoro-5-Methylbenzyl)Piperidin-4-Amine Dihydrochloride
CAS No.	1349716-49-9
Molecular Formula	C13H20Cl2FN3
Molecular Weight	308.22 g/mol
Synonyms	4-Amino-1-[(3-fluoro-5-methylphenyl)methyl]piperidine dihydrochloride; 1-[(3-Fluoro-5-methylphenyl)methyl]piperidin-4-amine dihydrochloride; N-[(3-Fluoro-5-methylphenyl)methyl]-4-piperidinamine dihydrochloride; 4-Piperidinamine, N-[(3-fluoro-5-methylphenyl)methyl]-, dihydrochloride; (3-Fluoro-5-methylbenzyl)(4-aminopiperidin-1-yl)methanone dihydrochloride (tautomer); 1349716-49-9; FC-1139 dihydrochloride (potential research code)
EINECS	Contact for details

Quality Control

Our n-(3-Fluoro-5-Methylbenzyl)Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.