Description

4-(Oxetan-3-Yloxy)-3-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional benzoic acid derivative featuring a unique oxetane ether moiety and a trifluoromethyl group. This combination of structural motifs makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active compounds. The compound's properties enable the fine-tuning of molecular characteristics such as metabolic stability, lipophilicity, and bioavailability in target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated monomer for creating advanced functional materials used in electronic displays.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and fragment-based drug discovery due to its unique three-dimensional oxetane scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex, proprietary molecules.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-(Oxetan-3-Yloxy)-3-(Trifluoromethyl)Benzoic Acid
CAS No.	1349716-44-4
Molecular Formula	C11H9F3O4
Molecular Weight	262.18 g/mol
Synonyms	3-(Trifluoromethyl)-4-(oxetan-3-yloxy)benzoic acid; 4-(Oxetan-3-yloxy)-3-(trifluoromethyl)benzoic acid; Benzoic acid, 4-(oxetan-3-yloxy)-3-(trifluoromethyl)-; 1349716-44-4; 3-Trifluoromethyl-4-(oxetan-3-yloxy)benzoic acid; 4-(3-Oxetanyloxy)-3-(trifluoromethyl)benzoic Acid; Oxetane-3-yloxy-trifluoromethyl-benzoic acid derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(Oxetan-3-Yloxy)-3-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.