Description

(R)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of central nervous system (CNS) and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates targeting G-protein coupled receptors (GPCRs).
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety for potential therapies in neurology and psychiatry.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Medicinal Chemistry Research: A valuable building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Biochemical Research: Potential use as a ligand or probe in biochemical assays and pharmacological studies.

Basic Information

Product Name	(R)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride
CAS No.	1349699-76-8
Molecular Formula	C9H20N2 • 2HCl
Molecular Weight	237.19 g/mol (Free base: 154.27 g/mol)
Synonyms	(3R)-1-(Cyclobutylmethyl)-3-pyrrolidinamine dihydrochloride; (R)-1-(Cyclobutylmethyl)pyrrolidin-3-amine hydrochloride (1:2); (R)-3-Amino-1-(cyclobutylmethyl)pyrrolidine dihydrochloride; UNII-4J3K1U4Y0F; Pyrrolidin-3-amine, 1-(cyclobutylmethyl)-, (3R)-, dihydrochloride; (R)-1-Cyclobutylmethyl-3-aminopyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.