Description

6-Tosyl-1-Oxa-6-Azaspiro[3.3]Heptan-3-One is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic structure.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and route development for potential APIs.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and target validation.

Basic Information

Product Name	6-Tosyl-1-Oxa-6-Azaspiro[3.3]Heptan-3-One
CAS No.	1349199-62-7
Molecular Formula	C12H13NO4S
Molecular Weight	267.30 g/mol
Synonyms	1-Oxa-6-azaspiro[3.3]heptan-3-one, 6-[(4-methylphenyl)sulfonyl]-; 6-(Tosyl)-1-oxa-6-azaspiro[3.3]heptan-3-one; 6-(4-Methylbenzenesulfonyl)-1-oxa-6-azaspiro[3.3]heptan-3-one; Tosyl Oxa-Azaspiroheptanone; Spirocyclic Tosylamide Ester; CAS 1349199-62-7
EINECS	Contact for details

Quality Control

Our 6-Tosyl-1-Oxa-6-Azaspiro[3.3]Heptan-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.