Description

6-Tosyl-2-Oxa-6-Azaspiro[3.3]Heptane-1-Carboxylic Acid is a high-value, multifunctional spirocyclic building block used in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used to construct the linker and warhead components of bifunctional PROTAC molecules for targeted protein degradation.
• Agrochemical Synthesis: Serves as a precursor for creating new generation herbicides and fungicides with spirocyclic motifs.
• Material Science Research: Employed in the development of specialty polymers and organic electronic materials due to its rigid, three-dimensional structure.
• Chemical Biology Probes: Utilized to create tool compounds and probes for studying enzyme function and biological pathways.
• Peptidomimetic Design: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.

Basic Information

Item	Detail
Product Name	6-Tosyl-2-Oxa-6-Azaspiro[3.3]Heptane-1-Carboxylic Acid
CAS No.	1349199-54-7
Molecular Formula	C13H15NO5S
Molecular Weight	297.33 g/mol
Synonyms	2-Oxa-6-azaspiro[3.3]heptane-1-carboxylic acid, 6-(4-methylbenzenesulfonyl)-; 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane-1-carboxylic acid; 6-Tosyl-2-oxa-6-azaspiro[3.3]heptane-1-carboxylic acid; 6-(Tosyl)-2-oxa-6-azaspiro[3.3]heptane-1-carboxylic acid; 6-(4-Methylphenyl)sulfonyl-2-oxa-6-azaspiro[3.3]heptane-1-carboxylic acid; Tosyl-Oxazaspiroheptane Carboxylic Acid; CAS 1349199-54-7
EINECS	Contact for details

Quality Control

Our 6-Tosyl-2-Oxa-6-Azaspiro[3.3]Heptane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.