Description

Cbz-n-Amido-Peg2-Acid CAS NO 1347750-76-8 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxybenzyl (Cbz) protecting group and an amide linkage. This compound is a critical building block in the synthesis of complex molecules, offering a hydrophilic spacer and a protected amine handle for precise bioconjugation and peptide/protein modification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug delivery systems, bioconjugate chemistry, and the development of novel therapeutics.

Application

• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to peptides, proteins, or antibodies, leveraging its hydrophilic PEG spacer to improve solubility and reduce immunogenicity.
• Peptide Synthesis Intermediate: Serves as a key building block in solid-phase and solution-phase peptide synthesis, where the Cbz group provides orthogonal protection for amine functionalities.
• Drug Delivery System Development: Incorporated into the design of prodrugs and polymer-drug conjugates to enhance pharmacokinetic properties, such as circulation time and targeted delivery.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Facilitates the controlled attachment of cytotoxic payloads to monoclonal antibodies via its cleavable or stable linker chemistry.
• Hydrogel and Biomaterial Functionalization: Employed to introduce reactive carboxylic acid groups into polymeric matrices for cross-linking or further modification in tissue engineering scaffolds.
• Diagnostic Reagent Preparation: Utilized in the synthesis of contrast agents or fluorescent probes for imaging and diagnostic assays.

Basic Information

Product Name	Cbz-n-Amido-Peg2-Acid
CAS No.	1347750-76-8
Molecular Formula	C₁₉H₂₇NO₇
Molecular Weight	381.42 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3-oxa-5,8,11-trioxatetradecan-14-oic acid; 17-[(Benzyloxy)carbonyl]amino-5,8,11-trioxa-2-azapentadecan-15-oic acid; Carbobenzoxy-PEG2-propionic acid; Z-NH-PEG2-CH2CH2COOH; Fmoc-N-amido-PEG2-acid (related); Cbz-NH-PEG2-COOH; N-Cbz-3,6-dioxa-8-aminooctanoic acid; Benzyl N-[2-[2-(2-carboxyethoxy)ethoxy]ethyl]carbamate
EINECS	Contact for details

Quality Control

Our Cbz-n-Amido-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.