Description

tert-Butyl 6-(Trifluoromethyl)-3,4-Dihydro-1,5-Naphthyridine-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound matters for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the dihydronaphthyridine scaffold.
• Organic Synthesis Building Block: Serves as a versatile reagent for introducing the trifluoromethyl-substituted 1,5-naphthyridine moiety into more complex molecular architectures.
• Agrochemical Research: Potential application in the synthesis of novel crop protection agents and herbicides due to its unique heterocyclic structure.
• Material Science Precursor: Can be utilized in the development of specialty chemicals and functional materials requiring fluorinated heterocycles.

Basic Information

Product Name	tert-Butyl 6-(Trifluoromethyl)-3,4-Dihydro-1,5-Naphthyridine-1(2H)-Carboxylate
CAS No.	1346809-60-6
Molecular Formula	C14H15F3N2O2
Molecular Weight	300.28 g/mol
Synonyms	1,5-Naphthyridine-1(2H)-carboxylic acid, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dimethylethyl ester; tert-Butyl 6-(trifluoromethyl)-1,2,3,4-tetrahydro-1,5-naphthyridine-1-carboxylate; 6-(Trifluoromethyl)-1,2,3,4-tetrahydro-1,5-naphthyridine-1-carboxylic acid tert-butyl ester; 1-Boc-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1,5-naphthyridine; Boc-6-CF3-1,2,3,4-tetrahydro-1,5-naphthyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Trifluoromethyl)-3,4-Dihydro-1,5-Naphthyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.