Description

5H-Pyrrolo[3,4-B]Pyridine-3-Carbonitrile, 6,7-Dihydro-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate with a unique fused heterocyclic structure. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Research and development teams in the pharmaceutical, biotechnology, and fine chemical sectors need this material to drive innovation in drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex polycyclic nitrogen-containing heterocycles, which are privileged scaffolds in drug design.
• Chemical Biology Research: Serves as a probe or a core structure in the development of enzyme inhibitors or receptor modulators for biological pathway studies.
• Agrochemical Research: Potential application as an intermediate in the synthesis of novel crop protection agents with specific biological activity.
• Material Science Exploration: Investigated as a precursor for the development of organic electronic materials due to its conjugated π-system and electron-withdrawing nitrile group.

Basic Information

Product Name	5H-Pyrrolo[3,4-B]Pyridine-3-Carbonitrile, 6,7-Dihydro-, Hydrochloride (1:1)
CAS No.	1346808-69-2
Molecular Formula	C9H8N3·HCl
Molecular Weight	193.64 g/mol (Free base: 158.18 g/mol)
Synonyms	6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine-3-carbonitrile hydrochloride; 5H-Pyrrolo[3,4-b]pyridine-3-carbonitrile, 6,7-dihydro-, hydrochloride; 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl cyanide hydrochloride; 3-Cyano-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride; 1H-Pyrrolo[3,4-b]pyridine-3-carbonitrile, 4,5,6,7-tetrahydro-, hydrochloride (tautomeric form); CAS 1346808-69-2
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[3,4-B]Pyridine-3-Carbonitrile, 6,7-Dihydro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR, NMR), and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.