Description

4-(3-Hydroxyoxetan-3-Yl)Benzoic Acid is a specialty heterocyclic aromatic carboxylic acid featuring a sterically hindered, hydroxyl-substituted oxetane ring directly attached to the para-position of the benzoic acid scaffold. This unique architecture imparts high functional group density, conformational rigidity, and enhanced metabolic stability—making it a strategically valuable building block for next-generation pharmaceuticals and advanced materials. It is primarily utilized by medicinal chemists and process R&D teams in global pharmaceutical and biotech companies developing protease inhibitors, kinase modulators, and covalent drug candidates. The compound is supplied under strict quality control to meet the demanding purity and consistency requirements of late-stage intermediate synthesis.

Application

• Key synthetic intermediate in the preparation of oral anticoagulants and thrombin inhibitors
• Building block for covalent PROTAC (Proteolysis-Targeting Chimera) linker design due to oxetane’s favorable physicochemical and stability profile
• Monomer or comonomer in high-performance polyesters and polyamides requiring thermal resilience and low moisture absorption
• Pharmacophore component in PET radiotracer development (e.g., 18F-labeled analogs via oxetane ring functionalization)
• Chiral derivatizing agent for asymmetric synthesis and enantioselective catalysis support ligands
• Structural motif in photoacid generators (PAGs) for advanced EUV lithography resists

Basic Information

Product Name	4-(3-Hydroxyoxetan-3-Yl)Benzoic Acid
CAS No.	1346608-76-1
Molecular Formula	C10H10O4
Molecular Weight	194.18 g/mol
Synonyms	4-(Oxetan-3-ylhydroxy)benzoic acid; 4-(3-Hydroxyoxetan-3-yl)benzoic acid; 3-(4-Carboxyphenyl)oxetan-3-ol; 4-[3-Hydroxy-3-(oxetan-3-yl)]benzoic acid; 4-(3-Hydroxyoxetan-3-yl)benzoic acid (CAS 1346608-76-1); Benzoic acid, 4-(3-hydroxy-3-oxetanyl)-; NSC 1015271; AKOS025111570; RT-013327
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, 1H NMR), assay (HPLC), residual solvents (GC), heavy metals (USP <231>), and water content (Karl Fischer). The material meets specifications appropriate for pharmaceutical intermediate use per ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling and dispensing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.