Description

Jwh 018 n-(3-Methylbutyl) Isomer is a synthetic cannabinoid research chemical belonging to the aminoalkylindole class, structurally characterized by a naphthoylindole core with an N-(3-methylbutyl) side chain. It serves as a critical reference standard for forensic toxicology, pharmaceutical R&D, and analytical method development due to its well-defined receptor binding profile and metabolic stability. This compound is primarily utilized by government laboratories, academic research institutions, and contract research organizations engaged in controlled substance monitoring, metabolite identification, and assay validation. Its high structural specificity supports reproducible pharmacological profiling under controlled experimental conditions.

Application

• Forensic toxicology screening and confirmation of novel psychoactive substances (NPS) in biological matrices
• Reference standard for LC-MS/MS and GC-MS method development and validation in clinical and crime lab settings
• Pharmacological research on CB1 and CB2 cannabinoid receptor affinity, selectivity, and functional activity
• Metabolic stability studies and human hepatocyte incubation experiments to identify phase I/II metabolites
• Calibration standard preparation for quantitative analysis in seized drug material characterization
• Quality control benchmark for synthetic cannabinoid impurity profiling and batch-to-batch consistency assessment
• Academic neuroscience research investigating structure-activity relationships (SAR) within the JWH series
• Regulatory compliance testing support for international narcotics control agencies (e.g., UNODC, EMCDDA)

Basic Information

Product Name	Jwh 018 n-(3-Methylbutyl) Isomer
CAS No.	1346604-93-0
Molecular Formula	C24H27NO
Molecular Weight	345.48 g/mol
Synonyms	JWH-018 N-(3-methylbutyl) isomer; JWH-018 3-methylbutyl analog; N-(3-Methylbutyl)-1-pentyl-1H-indol-3-yl(methoxy)methanone; 1-(5-Fluoropentyl)-3-(1-naphthoyl)indole isomer; JWH-018 N-isoamyl isomer; N-(Isoamyl)-JWH-018; 3-(1-Naphthoyl)-1-(5-fluoropentyl)indole (incorrectly cited in early literature); JWH-018 3-methylbutyl homolog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), and absence of key synthetic impurities (e.g., unreacted naphthoic acid, indole precursors) using validated methods aligned with ICH Q2(R2) and USP <1225> guidelines. Testing is performed in ISO/IEC 17025-accredited laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and degradation. Keep away from moisture and direct sunlight. Maintain in a well-ventilated area, isolated from strong oxidizing agents and alkaline materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances	Each ≤0.3%; Total ≤1.0%
Residue on Ignition	≤0.1%
Water (Karl Fischer)	≤0.2%
Solubility	Freely soluble in chloroform, methanol, and acetonitrile; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.