Description

Lofentanil-D3 Oxalate is a deuterated internal standard critical for precise analytical quantification in forensic and pharmaceutical research. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in method development and validation. It is primarily utilized by analytical laboratories, forensic toxicologists, and pharmaceutical R&D departments engaged in the study of potent synthetic opioids.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of lofentanil and related analogs in complex biological matrices.
• Forensic Toxicology: Essential for confirmatory testing and method validation in forensic laboratories analyzing post-mortem and human performance samples.
• Pharmacokinetic Studies: Enables precise measurement of drug concentration in plasma, serum, and tissue for absorption, distribution, metabolism, and excretion (ADME) research.
• Pharmaceutical Impurity Profiling: Supports the identification and quantification of potential impurities or degradation products in drug substance and product analysis.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring regulatory compliance in testing protocols.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites using high-resolution mass spectrometry techniques.

Basic Information

Product Name	Lofentanil-D3 Oxalate
CAS No.	1346599-64-1
Molecular Formula	C23H29D3N2O5
Molecular Weight	Contact for details
Synonyms	Lofentanil-d3; Lofentanil (phenyl-d3) oxalate; N-(2-(4-Ethoxycarbonyl-4-(N-phenyl-d5-propanamido)piperidin-1-yl)ethyl)-N-phenylpropanamide oxalate; 4-[(1-Oxopropyl)phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylic acid ethyl ester-d3 oxalate; Lofentanil D3 (Oxalate Salt); Deuterated Lofentanil Oxalate
EINECS	Contact for details

Quality Control

Our Lofentanil-D3 Oxalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic purity (deuterium incorporation), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.