Description

2,2-Difluoro-3-(Methylamino)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its difluoromethyl and methylamino functional groups. This compound serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis, enabling the introduction of fluorine atoms to modulate the biological activity and metabolic stability of target molecules. It is essential for researchers and manufacturers in medicinal chemistry and process development for creating novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated peptide mimetics and small molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the effects of fluorine substitution on potency and pharmacokinetics.
• API Process Development: Serves as a building block in the scalable manufacturing routes for fluorinated active pharmaceutical ingredients.
• Bioconjugation & Probe Synthesis: Utilized for labeling and modifying biomolecules due to its reactive carboxylic acid and amine functionalities.
• Agrochemical Research: Employed in the development of novel fluorinated pesticides and herbicides.
• Material Science: A potential monomer or modifier for creating specialty polymers with unique properties.

Basic Information

Product Name	2,2-Difluoro-3-(Methylamino)Propanoic Acid Hydrochloride
CAS No.	1346597-54-3
Molecular Formula	C4H8F2NO2 • HCl
Molecular Weight	185.57 g/mol (Free base: 149.11 g/mol)
Synonyms	3-(Methylamino)-2,2-difluoropropanoic acid hydrochloride; 2,2-Difluoro-3-(methylamino)propionic acid HCl; DL-2,2-Difluoro-3-(methylamino)propanoic acid hydrochloride; Methylamino-difluoropropionic acid hydrochloride; (RS)-2,2-Difluoro-3-(methylamino)propanoic acid hydrochloride; 1346597-54-3; 2,2-Difluoro-3-(methylamino)propanoic acid, hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-3-(Methylamino)Propanoic Acid Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide full traceability and Certificates of Analysis (COA) with every shipment, ensuring compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.