Description

Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-(Hydroxyimino)-, 1,1-Dimethylethyl Ester, (4E)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and oxime functional groups. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable, high-quality building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential therapeutic agents, especially for neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic frameworks and spiro compounds.
• Preclinical Development: Employed in the production of compounds for pharmacological and toxicological evaluation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and chemical biology.

Basic Information

Product Name	Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-(Hydroxyimino)-, 1,1-Dimethylethyl Ester, (4E)-
CAS No.	1346497-68-4
Molecular Formula	C19H24N2O4
Molecular Weight	344.41 g/mol
Synonyms	(4E)-3,4-Dihydro-4-(hydroxyimino)spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl (4E)-3,4-dihydro-4-(hydroxyimino)spiro[2H-chromene-2,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl (4E)-3,4-dihydro-4-(hydroxyimino)spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; Spiro[chromene-2,4'-piperidine] oxime derivative; CAS 1346497-68-4
EINECS	Contact for details

Quality Control

Our Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-4-(Hydroxyimino)-, 1,1-Dimethylethyl Ester, (4E)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and prolonged exposure to air; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.