Description

3-Azaspiro[5.5]Undecane-9-Acetic Acid, 3-[(1,1-Dimethylethoxy)Carbonyl]-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and protected amino acid ester structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides due to its spirocyclic scaffold, which can mimic peptide secondary structures.
• Medicinal Chemistry & Lead Optimization: Employed to introduce structural complexity and specific stereochemistry into lead compounds to improve potency, selectivity, and metabolic stability.
• Process Chemistry Development: Utilized in scaling up synthetic routes for potential APIs during late-stage research and development phases.
• Bioconjugation and Probe Development: The reactive ester and protected amine functionalities make it suitable for creating chemical probes for biological target identification and validation.

Basic Information

Product Name	3-Azaspiro[5.5]Undecane-9-Acetic Acid, 3-[(1,1-Dimethylethoxy)Carbonyl]-, Methyl Ester
CAS No.	1346229-41-1
Molecular Formula	C17H29NO4
Molecular Weight	311.42 g/mol
Synonyms	Methyl 3-(tert-butoxycarbonyl)-3-azaspiro[5.5]undecane-9-acetate; 3-(Boc)-3-azaspiro[5.5]undecane-9-acetic acid methyl ester; Boc-3-azaspiro[5.5]undecane-9-acetic acid methyl ester; 3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; 3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-acetic Acid Methyl Ester; Spirocyclic amino acid ester intermediate; CAS 1346229-41-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and purified using techniques such as column chromatography and recrystallization, followed by comprehensive analytical verification via NMR, HPLC, and MS to ensure structural integrity and high purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.