Description

Benzoic Acid, 4-(6-Methyl-1,2,4,5-Tetrazin-3-Yl)- is a high-value, heterocyclic-functionalized benzoic acid derivative that serves as a critical building block in advanced chemical synthesis. This compound matters for its unique tetrazine moiety, which enables highly specific bioorthogonal click chemistry reactions, a cornerstone technology in modern life sciences. It is primarily needed by pharmaceutical researchers, bioconjugation specialists, and agrochemical developers for creating targeted probes, drug conjugates, and novel active ingredients.

Application

• Bioorthogonal Chemistry & Bioconjugation: As a key reagent for inverse electron demand Diels-Alder (IEDDA) click reactions with trans-cyclooctenes (TCOs) for labeling biomolecules in live cells.
• Pharmaceutical Research & Development: For the synthesis of targeted drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic imaging agents.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and the development of chemical probes to study biological processes.
• Material Science & Polymer Chemistry: As a functional monomer or cross-linker for creating smart polymers and surfaces with specific, triggerable properties.
• Agrochemical Innovation: Serving as a synthetic intermediate for novel herbicides or pesticides with targeted modes of action.
• Academic & Industrial R&D: A versatile scaffold for exploring new chemical space in medicinal chemistry and catalyst design.

Basic Information

Product Name	Benzoic Acid, 4-(6-Methyl-1,2,4,5-Tetrazin-3-Yl)-
CAS No.	1345866-66-1
Molecular Formula	C10H8N4O2
Molecular Weight	216.20 g/mol
Synonyms	4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid; 3-(4-Carboxyphenyl)-6-methyl-1,2,4,5-tetrazine; 6-Methyl-3-(4-carboxyphenyl)-1,2,4,5-tetrazine; Methyltetrazine-PEG4-acid (core structure); m-Tetrazine-COOH; Bioorthogonal Tetrazine Acid; TZ-COOH; Click Chemistry Tetrazine Reagent
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-(6-Methyl-1,2,4,5-Tetrazin-3-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.