Description

(2R)-2-(Difluoromethyl)Pyrrolidine Hcl is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its unique difluoromethylated pyrrolidine scaffold, which is critical for modulating the physicochemical and metabolic properties of bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in medicinal chemistry for drug discovery and process chemistry for API synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Medicinal Chemistry Research: Used as a building block for constructing compound libraries to explore structure-activity relationships (SAR) and optimize drug candidates.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereocenters.
• Proteolysis Targeting Chimera (PROTAC) Development: Incorporated into linker designs to confer favorable pharmacokinetic properties.
• Agrochemical Research: Employed in the discovery of novel pesticides and herbicides that leverage fluorine chemistry for enhanced activity.
• Ligand and Catalyst Design: Used to develop novel chiral ligands for transition metal catalysis.

Basic Information

Product Name	(2R)-2-(Difluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1344581-87-8
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	(R)-2-(Difluoromethyl)pyrrolidine hydrochloride; (2R)-2-(Difluoromethyl)-1-azacyclopentane hydrochloride; Pyrrolidine, 2-(difluoromethyl)-, (2R)-, hydrochloride; (R)-2-Difluoromethylpyrrolidine HCl; (R)-2-(Difluoromethyl)pyrrolidine HCl salt; (2R)-2-Difluoromethylpyrrolidine hydrochloride; (R)-2-(Difluoromethyl)pyrrolidine monohydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-(Difluoromethyl)Pyrrolidine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-grade standards for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.