Description

2-((1R)-1-Aminoethyl)-3-Bromophenol is a chiral, multifunctional organic building block of significant interest in advanced chemical synthesis. Its core value lies in the strategic combination of a phenolic hydroxyl group, a bromine substituent, and a chiral aminoethyl side chain, enabling its use as a key intermediate for constructing complex, optically active molecules. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for applications such as asymmetric synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the asymmetric synthesis of potential drug candidates, particularly for molecules requiring a phenethylamine or amino alcohol pharmacophore.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or plant growth regulators where its halogenated phenolic structure can be leveraged for bioactivity.
• Ligand and Catalyst Precursor: The chiral amine and phenol functionalities make it a valuable starting material for synthesizing specialized ligands used in asymmetric catalysis (e.g., for hydrogenation or cross-coupling reactions).
• Material Science Monomer: Potential use in the synthesis of specialized polymers or resins, where the bromine group allows for further functionalization or cross-linking.
• Chemical Biology Probe Synthesis: Employed in creating tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A high-value intermediate for fine chemical suppliers offering bespoke synthesis services to clients in life sciences.

Basic Information

Product Name	2-((1R)-1-Aminoethyl)-3-Bromophenol
CAS No.	1344438-63-6
Molecular Formula	C8H10BrNO
Molecular Weight	216.08 g/mol
Synonyms	(1R)-1-(3-Bromo-2-hydroxyphenyl)ethan-1-amine; (R)-1-(3-Bromo-2-hydroxyphenyl)ethanamine; 3-Bromo-2-[(1R)-1-aminoethyl]phenol; 2-[(1R)-1-Aminoethyl]-3-bromophenol; (R)-2-(1-Aminoethyl)-3-bromophenol; 3-Bromo-2-((R)-1-aminoethyl)phenol; (R)-1-(3-Bromo-2-hydroxyphenyl)ethylamine
EINECS	Contact for details

Quality Control

Our 2-((1R)-1-Aminoethyl)-3-Bromophenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and cGMP standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.