Description

4-Chloro-8-Fluoro-3-Isopropyl-2-Methyl-Quinoline CAS NO 1343392-03-9 is a high-purity, multi-substituted quinoline derivative serving as a critical advanced intermediate in modern organic synthesis. Its unique halogenated and alkylated structure makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used as a precursor in the creation of new-generation herbicides, fungicides, and insecticides, leveraging the quinoline core for bioactivity.
• Material Science Research: Serves as a functional monomer or ligand precursor in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags or molecular probes for studying biological processes and enzyme mechanisms.
• Catalyst Ligand Development: The nitrogen-containing heterocycle can be utilized to develop novel ligands for transition metal catalysis in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-8-Fluoro-3-Isopropyl-2-Methyl-Quinoline
CAS No.	1343392-03-9
Molecular Formula	C₁₃H₁₃ClFN
Molecular Weight	237.70 g/mol
Synonyms	4-Chloro-8-fluoro-3-(propan-2-yl)-2-methylquinoline; 3-Isopropyl-2-methyl-4-chloro-8-fluoroquinoline; 2-Methyl-4-chloro-8-fluoro-3-isopropylquinoline; Quinoline, 4-chloro-8-fluoro-3-(1-methylethyl)-2-methyl-; 1343392-03-9; 4-Chloro-8-fluoro-3-isopropyl-2-methylquinoline
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-8-Fluoro-3-Isopropyl-2-Methyl-Quinoline adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed via advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.