Description

8-(Chloromethyl)-5-Fluoroquinoline is a versatile and high-value fluorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a fluorine atom, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel fluoroquinolone-based antibiotics and other therapeutic agents.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, leveraging the bioactivity of the quinoline scaffold.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and organic electronic materials.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions and for introducing the quinoline moiety into more complex structures.
• Ligand & Catalyst Development: Utilized in the preparation of nitrogen-containing ligands for metal catalysis.
• Life Science Research: Employed as a biochemical tool and probe in medicinal chemistry and drug discovery programs.

Basic Information

Product Name	8-(Chloromethyl)-5-Fluoroquinoline
CAS No.	1342349-11-4
Molecular Formula	C₁₀H₇ClFN
Molecular Weight	195.62 g/mol
Synonyms	5-Fluoro-8-(chloromethyl)quinoline; 8-Chloromethyl-5-fluoroquinoline; Quinoline, 8-(chloromethyl)-5-fluoro-; 5-Fluoro-8-quinolinemethyl chloride
EINECS	Contact for details

Quality Control

Our 8-(Chloromethyl)-5-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting purity, impurity profiles, and other critical parameters to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.